COVID-19 a complex multi-organ disease requires comprehensive diagnostic solutions

HUMAN supports laboratories with comprehensive solutions for the diagnosis of a wide range of aspects of COVID-19. For triage of SARS-CoV-2 patients, parameters of hematology and clinical chemistry are recommended. Coagulation parameters provide information on the prognosis of the patients.
In addition, the detection of antibodies in response to coronavirus infection is becoming increasingly important. Antibody detection is used, for example, to identify patients in later stages of infection or with previous infections, as well as for seroprevalence and epidemiological studies.
To meet the worldwide demand for specific and sensitive SARS CoV-2 antibody tests, HUMAN has signed a global distribution agreement with Beijing Wantai BioPharm, one of the leading manufacturers of diagnostics for infectious diseases.

Rapid Test - For the detection of antibodies of class IgM, IgG and IgA in one total Ab test

Wantai SARS-CoV-2 Ab Rapid Test for high sensitivity

REFWJ-2750
ProductRapid Test
Ig classTotal Ab = IgM + IgG + IgA
Labeling proteinS1-RBD (receptor binding domain)
Sensitivity/Specificity98,89%/94,7%
Sample10µl blood (venous, or capillary), serum, plasma
Tests/kit50, incl. buffer
ApprovalCE mark

Serological tests like the colloidal gold RDT, detect antibodies in the blood. They provide a positive result when an immune reaction to the pathogen has already taken place.

ELISA - For qualitative detection of total antibodies of class IgM, IgG and IgA to the SARS-CoV-2 virus

Wantai SARS-CoV-2 Ab ELISA

REFWS-1096
ProductELISA
Ig classTotal Ab = IgM + IgG + IgA
Labeling proteinS1-RBD (receptor binding domain)
Sensitivity/Specificity94.36%/100%
Sample100µl serum or plasma
Tests/kit96 x 1
ApprovalCE mark

The ELISA detects total antibodies (IgM, IgG and IgA) as indicative of an immune response to SARS-CoV-2 in patients suspected of previous SARS-CoV-2 infection, or for the detection of seroconversion in patients following known recent SARS-CoV-2 infection. The test may also be used to aid in the diagnosis of acute or past SARS-CoV-2 infection in conjunction with other tests and clinical information.

  • Specific detection of antibodies using the S1 domain of the spike protein including the immunologically relevant receptor binding domain (RBD)
  • RBD is an important target antigen for virus neutralizing antibodies
  • Fully automatic processing and result analysis with HUMAN ELISA instruments possible

"The first detectible serology marker with the highest sensitivity is total antibody"1 

1Lou B. et al. 2020 Serology characteristics of SARS-CoV-2 infection since the exposure and post symptoms onset 

COVID-19 related diagnostic solutions

Genetic characteristics influence susceptibility to COVID-19 Blood group A a risk factor for COVID-19?

The rapid global spread of the noval SARS-CoV-2 virus is straining existing health resources, so identifying infected persons and prioritising people at high risk has become a critical challenge.

Publication about COVID-19 Kidney disease

An early warning for severity and complications
Several publications indicate that the novel coronavirus SARS-CoV-2 does not only affect the lungs but also impacts numerous other organs, like kidneys which have been observed to be the second most frequently affected organs.

Main laboratory abnormalities associated with COVID-19

Although RT-PCR is the recommended testing for diagnosis of a SARS-CoV-2 infection, there are numerous other diagnostic parameters that show abnormal laboratory results in COVID-19 patients. 

Supporting faster triage of COVID-19 patients by the use of hematology and CRP

In many countries, health organizations fear that they will find themselves in a situation where too many patients seek help in clinics, similar to the COVID 19 outbreak in Wuhan/China.

ISTH interim guidance on recognition and management of coagulopathy in COVID-19

According to recent observations, coagulopathy often occurs in severe cases of COVID-19 patients. Coagulopathy is a condition in which the ability of the blood to clot is impaired - a term that includes the thrombotic state in sepsis.

Hemostasis parameters as prognostic markers in COVID-19 patients

Is there a relationship between COVID-19 and hemostasis? A recent article by Lippi and Plebani provides an overview on the most frequent laboratory abnormalities encountered in patients with COVID-2019 infection.

Upcoming webinars

Supporting faster triage of COVID-19 patients through the use of hematology and the role of blood groups in SARS-CoV-2 infection

Get an overview on strategies of fast decision makings on COVID-19 patients and learn about blood groups as a risk factor for a severe progress the disease. Use the chance to exchange ideas with our product specialists in hematology and blood grouping.

  • Tuesday, August 4, 2020
    09:00 - 09:30 AM CEST

SARS-CoV-2 antibody testing - the when, the what and the how

Learn about when antibody testing is most valuable, what you have to consider when choosing a test and how HUMAN provides solutions. Discuss the RDT and ELISA solutions provided by HUMAN with our experts.

  • Tuesday, August 11, 2020
    10:00 - 10:45 AM CEST

Webinars on demand

Thromboinflammation in COVID-19: the importance of D-dimer and coagulation assays

Thrombotic and inflammatory events both contribute to acute organ damage in thromboinflammation, which is a  typical  characteristic of a severe course of COVID-19. 

Supporting faster triage of COVID-19 patients by the use of hematology and CRP

Learn more about the clinical and technical background also regarding COVID-19 for this very interesting win-win relationship and discuss with our specialists for hematology and COVID-19.

The importance of D-dimer and other Hemostasis parameters in COVID-19 patients

Learn more about the clinical background regarding the importance of D-dimer and other Hemostasis parameters

Publications

COVID-19 Publication List

This document contains a selection of relevant scientific publications related to COVID-19.The content has been compiled to the best of our knowledge and belief and makes no claim to completeness or correctness.

Press Release

Distribution agreement on a global scale on serological tests to detect exposure to COVID-19

HUMAN Gesellschaft für Biochemica und Diagnostica mbH, signed a distribution agreement on a global scale for antibody related COVID-19 products. The...