Roche Cobas e411 or HumaCLIA 150: Which Immunoassay Analyzer To Choose?

Chemiluminescence immunoassay (CLIA) analyzers such as the HumaCLIA 150 and Roche Cobas e411 offer advanced features and capabilities to meet the diverse needs of today's diagnostic laboratories. Understanding the specific benefits of each model can help you select the optimal instrument for your laboratory's needs.


Company HUMAN Roche
Model HumaCLIA 150 Cobas e411
Type of Instrument Benchtop Benchtop
Mode Continuous access Continuous access
Detection based on Acridinium ester (AE) Electro-chemiluminescence (ECL)
Throughput (up to) 150 t/h 86 t/h
Assay time approx. 30 min approx. 15 min
Reagent positions 20 refrigerated 18
Sample positions 50 30 with disc-based version, 75 with rack-based version
STAT positions (Emergency samples) 50 yes
Reaction cuvettes onboard capacity 1000 cuvettes 60 cuvettes
Cuvette format Single cuvettes in bulk format Cuvettes in a box

*All information is correct as of March 2024



Selecting the right bench-top immunoassay analyzer can significantly enhance laboratory efficiency and accuracy. This comparison between the HUMAN HumaCLIA 150 and Roche Cobas e411 highlights their key features to help you decide which one best meets your laboratory needs.

Instrument Type and Mode

Both the HumaCLIA 150 and the Cobas e411 are bench-top immunoassay analyzers designed for continuous access operation. This mode allows for the uninterrupted addition of samples, reagents, and consumables, enhancing workflow efficiency and accommodating varying test volumes.

HumaCLIA 150: Operates as a bench-top analyzer with continuous access mode, allowing for efficient handling of samples and reagents without workflow interruption.

Cobas e411: Similarly, the Cobas e411 functions as a bench-top analyzer with continuous access mode, providing consistent operational efficiency for various laboratory sizes.

Detection Methods

The detection method is a crucial factor in determining the analyzer's sensitivity and specificity, directly impacting the accuracy of test results.

HumaCLIA 150: Utilizes Acridinium Ester (AE) for detection, a chemiluminescent substrate known for its high sensitivity and specificity, making it ideal for accurate diagnostic testing.

Cobas e411: Employs Electro-Chemiluminescence (ECL) technology, which combines electrochemical and chemiluminescent techniques to provide precise and reliable results, ensuring robust analytical performance.

Throughput and Assay Time

Throughput is essential for laboratories that handle high sample volumes, determining how many tests can be processed within a given timeframe. Assay time affects the speed at which individual tests are completed.

HumaCLIA 150: Offers a maximum throughput of 150 tests per hour, making it suitable for high-volume testing environments. The assay time is approximately 30 minutes, balancing rapid processing with comprehensive analysis.

Cobas e411: Provides a lower throughput of 86 tests per hour, which may be more suitable for laboratories with moderate sample volumes. However, it compensates with a shorter assay time of approximately 15 minutes, allowing for quicker test completion.

Reagent Positions

The number of reagent positions influences the analyzer's flexibility in conducting various tests and the frequency of reagent changes required.

HumaCLIA 150: Equipped with 20 refrigerated reagent positions, this model supports a wide range of tests and reduces the need for frequent reagent replacement, enhancing operational efficiency.

Cobas e411: Features 18 reagent positions, which, while slightly fewer, still offer significant capacity for diverse assays and efficient reagent management.

Sample Positioning

Adequate sample positions are crucial for managing sample volumes effectively, preventing backlogs, and maintaining smooth laboratory operations.

HumaCLIA 150: Provides 50 sample positions, catering to higher sample volumes and including provisions for urgent STAT samples, ensuring timely processing of all samples.

Cobas e411: Offers flexibility with 30 sample positions in the disc-based version and up to 75 sample positions in the rack-based version, accommodating various laboratory needs and sample volumes.

STAT Sample Handling

Handling STAT (emergency) samples efficiently is vital for clinical laboratories, ensuring priority processing without disrupting routine workflows.

HumaCLIA 150: Integrates STAT sample handling within its 50 sample positions, allowing for seamless inclusion of urgent tests in the workflow.

Cobas e411: Includes dedicated STAT sample handling capabilities, ensuring that emergency samples are processed promptly, which is critical for urgent diagnostic needs.

Reaction Cuvettes Onboard Capacity

The onboard capacity of reaction cuvettes affects how long the analyzer can operate without needing cuvette replacement, impacting efficiency and workflow continuity.

HumaCLIA 150: Boasts a substantial onboard capacity of 1000 reaction cuvettes, supporting extended continuous operation and reducing the frequency of interruptions for cuvette replacement.

Cobas e411: Features a capacity of 60 cuvettes, which may require more frequent replacements but supports efficient test processing for moderate sample volumes.

Cuvette Format

The format of cuvettes can influence the ease of use, operational efficiency, and cost-effectiveness of the analyzer.

HumaCLIA 150: Uses single cuvettes in a bulk format, advantageous for high-volume testing environments due to easier handling and lower costs.

Cobas e411: Utilizes cuvettes in a box format, which may offer different operational benefits based on laboratory preferences and workflow requirements.


The choice between the HumaCLIA 150 and Cobas e411 should be based on the specific priorities and requirements of your laboratory. Considerations include testing volume, reagent and sample capacity, STAT sample handling, and cuvette management. By evaluating these factors, laboratories can make a well-informed decision that aligns with their operational needs and testing demands.


Use the following form for any request whether it is product related or concerning potential distribution partnership.
Fields marked with a * are mandatory. Please take care in entering all data correctly.