Mindray CL-1000i or HumaCLIA 150: Which Immunoassay Analyzer To Choose?

Chemiluminescence immunoassay (CLIA) analyzers such as the HumaCLIA 150 and CL-1000i offer advanced features and capabilities to meet the diverse needs of today's diagnostic laboratories. Understanding the specific benefits of each model can help you select the optimal instrument for your laboratory's needs.


Company HUMAN Mindray
Model HumaCLIA 150 CL-1000i
Type of Instrument Benchtop Benchtop
Mode Continuous access Continuous access
Detection based on Acridinium ester (AE) Alkaline phosphatase (ALP)
Throughput (up to) 150 t/h 120 t/h
Assay time approx. 30 min 20 min
Reagent positions 20 refrigerated 25
Sample positions 50 60
STAT positions (Emergency samples) 50 yes
Reaction cuvettes onboard capacity 1000 cuvettes 176 cuvettes
Cuvette format Single cuvettes in bulk format 88 cuvettes on plates

*All information is correct as of March 2024



Selecting the right immunoassay analyzer can significantly enhance laboratory efficiency and accuracy. This comparison between the HUMAN HumaCLIA 150 and Mindray CL-1000i highlights their key features to help you decide which one best meets your laboratory needs.

Detection based on

The detection method used in immunoassay analyzers significantly affects the sensitivity and specificity of the tests, impacting the accuracy and reliability of results. Here's a detailed look at the differences between Acridinium ester (AE) and Alkaline phosphatase (ALP) detection methods:

  • HumaCLIA 150:
    Acridinium Ester (AE) -  is a chemiluminescent substrate used in immunoassays. When the acridinium ester-labeled antigen or antibody binds to its target, a chemical reaction is triggered. This reaction involves the oxidation of the acridinium ester, which produces light. The intensity of this light is measured and correlates directly with the amount of target substance present in the sample. AE-based detection is known for its high sensitivity and specificity, making it suitable for detecting low-abundance analytes. Key benefits include:
    • High Sensitivity: Capable of detecting very low levels of analytes, which is critical for assays requiring high precision.
    • High Specificity: Reduces the likelihood of cross-reactivity, ensuring accurate results.
    • Rapid Results: The chemiluminescent reaction is fast, allowing for quick turnaround times.
  • CL-1000i:

    Alkaline Phosphatase (ALP) -  is an enzyme used in chemiluminescent immunoassays. In ALP-based detection, the enzyme catalyzes a reaction with a chemiluminescent substrate (such as dioxetane). This reaction produces light, and the intensity of the light is proportional to the concentration of the target analyte in the sample. ALP-based assays are reliable and effective for a wide range of tests. Key benefits include:

    • Versatility: Suitable for various types of immunoassays, providing flexibility in the types of tests that can be performed.
    • Stable Signal: ALP reactions tend to produce a stable and sustained light signal, which can be advantageous for certain types of assays.
    • Robustness: ALP-based assays are known for their reliability and consistency in results.

Throughput (up to)

Throughput capacity is crucial for laboratories with high sample volumes, as it determines the number of tests processed per hour, impacting overall efficiency and productivity.

  • HumaCLIA 150: Offers a maximum throughput of 150 tests per hour, ideal for high-volume testing environments.
  • CL-1000i: Provides a throughput of 120 tests per hour, suitable for medium to high-volume laboratories.

Assay time

Assay time influences the speed at which individual tests are completed, affecting the turnaround time for results and overall laboratory workflow.

  • HumaCLIA 150: Has an approximate assay time of 30 minutes, providing a balance between rapid processing and detailed analysis.
  • CL-1000i: Features a shorter assay time of approximately 20 minutes, allowing for quicker results and enhanced throughput.

Reagent positions

The number of reagent positions is critical for laboratories conducting diverse tests, as it determines how many different assays can be run without frequent reagent changes.

  • HumaCLIA 150: Equipped with 20 refrigerated reagent positions, supporting a wide range of tests and minimizing reagent change frequency.
  • CL-1000i: Offers 25 reagent positions, providing more capacity for various assays and reducing the need for frequent reagent changes.

Sample positions

Adequate sample positions are essential for managing sample volumes effectively, preventing backlogs, and ensuring smooth laboratory operations.

  • HumaCLIA 150: Provides 50 sample positions, catering to higher sample volumes and including provisions for urgent STAT samples.
  • CL-1000i: Offers 60 sample positions, accommodating larger sample volumes and enhancing operational efficiency.

STAT positions (Emergency samples)

Efficient handling of STAT (emergency) samples is vital for clinical laboratories, ensuring priority processing without disrupting routine workflows.

  • HumaCLIA 150: Integrates STAT sample handling within its 50 sample positions, allowing for seamless inclusion of urgent tests.
  • CL-1000i: Includes dedicated STAT sample handling capabilities, ensuring prompt processing of emergency samples.

Reaction cuvettes onboard capacity

Onboard cuvette capacity is essential for ensuring the analyzer can handle a high number of reactions without frequent interruptions for reloading, thus supporting continuous and efficient workflow.

  • HumaCLIA 150: Has a capacity of 1000 cuvettes, supporting high-throughput operations.
  • CL-1000i: Provides a capacity of 176 cuvettes, which is lower than HumaCLIA 150 and may require more frequent reloading.

Cuvette format

The format of the cuvettes impacts ease of handling and loading efficiency. This feature is vital for maintaining smooth operations and reducing the time needed for manual interventions.

  • HumaCLIA 150: Uses single cuvettes in bulk format, which facilitates easy handling and loading, contributing to efficient laboratory workflow.
  • CL-1000i: Utilizes 88 cuvettes on plates, which can streamline the process but may require more handling compared to single cuvettes in bulk format.


The choice between the HumaCLIA 150 and CL-1000i should be based on the specific priorities and requirements of your laboratory. Considerations include testing volume, reagent and sample capacity, STAT sample handling, assay time, and cuvette management. By evaluating these factors, laboratories can make a well-informed decision that aligns with their operational needs and testing demands.


Use the following form for any request whether it is product related or concerning potential distribution partnership.
Fields marked with a * are mandatory. Please take care in entering all data correctly.