IDS iSYS or HumaCLIA 150: Which Immunoassay Analyzer To Choose?

Chemiluminescence immunoassay (CLIA) analyzers such as the HumaCLIA 150 and iSYS offer advanced features and capabilities to meet the diverse needs of today's diagnostic laboratories. Understanding the specific benefits of each model can help you select the optimal instrument for your laboratory's needs.


Model HumaCLIA 150 iSYS
Type of Instrument Benchtop Benchtop
Mode Continuous access Continuous access
Detection based on Acridinium ester (AE) Isoluminol
Throughput (up to) 150 t/h 120 t/h
Assay time approx. 30 min 30 min
Reagent positions 20 refrigerated 15 refrigerated
Sample positions 50 120
STAT positions (Emergency samples) 50 yes
Reaction cuvettes onboard capacity 1000 cuvettes 960 cuvettes
Cuvette format Single cuvettes in bulk format Single cuvettes in a box

*All information is correct as of March 2024



Selecting the right immunoassay analyzer can significantly enhance laboratory efficiency and accuracy. This comparison between the HUMAN HumaCLIA 150 and IDS iSYS highlights their key features to help you decide which one best meets your laboratory needs.

Detection based on

The detection method used in immunoassay analyzers significantly affects the sensitivity and specificity of the tests, impacting the accuracy and reliability of results. Here's a detailed look at the differences between Acridinium ester (AE) and Isoluminol detection methods:

  • HumaCLIA 150:

    Acridinium Ester (AE) - AE is a chemiluminescent substrate used in immunoassays. When the acridinium ester-labeled antigen or antibody binds to its target, a chemical reaction is triggered. This reaction involves the oxidation of the acridinium ester, which produces light. The intensity of this light is measured and correlates directly with the amount of target substance present in the sample. AE-based detection is known for its high sensitivity and specificity, making it suitable for detecting low-abundance analytes. Key benefits include:

    • High Sensitivity: Capable of detecting very low levels of analytes, which is critical for assays requiring high precision.
    • High Specificity: Reduces the likelihood of cross-reactivity, ensuring accurate results.
    • Rapid Results: The chemiluminescent reaction is fast, allowing for quick turnaround times.
  • iSYS:

    Isoluminol - is a chemiluminescent substrate used in immunoassays. In isoluminol-based detection, the substrate is oxidized in the presence of a catalyst, producing light. The intensity of this light is proportional to the concentration of the analyte in the sample. Isoluminol is known for its stability and robustness. Key benefits include:

    • Stability: Provides stable signal generation, which is important for consistent results.
    • Robustness: Suitable for a variety of assays, offering reliable performance.
    • Cost-Effective: Often less expensive than other chemiluminescent substrates, making it a cost-effective option.

Throughput (up to)

Throughput capacity is crucial for laboratories with high sample volumes, as it determines the number of tests processed per hour, impacting overall efficiency and productivity.

  • HumaCLIA 150: Offers a maximum throughput of 150 tests per hour, ideal for high-volume testing environments.
  • iSYS: Provides a throughput of 120 tests per hour, suitable for medium to high-volume laboratories.

Assay time

Assay time influences the speed at which individual tests are completed, affecting the turnaround time for results and overall laboratory workflow.

  • HumaCLIA 150: Has an approximate assay time of 30 minutes, providing a balance between rapid processing and detailed analysis.
  • iSYS: Also features an assay time of approximately 30 minutes, aligning closely with the HumaCLIA 150 for efficient testing.

Reagent positions

The number of reagent positions is critical for laboratories conducting diverse tests, as it determines how many different assays can be run without frequent reagent changes.

  • HumaCLIA 150: Equipped with 20 refrigerated reagent positions, supporting a wide range of tests and minimizing reagent change frequency.
  • iSYS: Offers 15 refrigerated reagent positions, which may require more frequent changes but is sufficient for streamlined testing protocols.

Sample positions

Adequate sample positions are essential for managing sample volumes effectively, preventing backlogs, and ensuring smooth laboratory operations.

  • HumaCLIA 150: Provides 50 sample positions, catering to higher sample volumes and including provisions for urgent STAT samples.
  • iSYS: Offers 120 sample positions, significantly higher than HumaCLIA 150, accommodating larger sample volumes and enhancing operational efficiency.

STAT positions (Emergency samples)

Efficient handling of STAT (emergency) samples is vital for clinical laboratories, ensuring priority processing without disrupting routine workflows.

  • HumaCLIA 150: Integrates STAT sample handling within its 50 sample positions, allowing for seamless inclusion of urgent tests.
  • iSYS: Includes dedicated STAT sample handling capabilities, ensuring prompt processing of emergency samples.

Reaction cuvettes onboard capacity

Onboard cuvette capacity is essential for ensuring the analyzer can handle a high number of reactions without frequent interruptions for reloading, thus supporting continuous and efficient workflow.

  • HumaCLIA 150: Has a capacity of 1000 cuvettes, supporting high-throughput operations.
  • iSYS: Provides a capacity of 960 cuvettes, which is slightly lower than HumaCLIA 150 but still supports high-throughput needs.

Cuvette format

The format of the cuvettes impacts ease of handling and loading efficiency. This feature is vital for maintaining smooth operations and reducing the time needed for manual interventions.

  • HumaCLIA 150: Uses single cuvettes in bulk format, which facilitates easy handling and loading, contributing to efficient laboratory workflow.
  • iSYS: Utilizes single cuvettes in a box, which can streamline the process but may require more handling compared to single cuvettes in bulk format.


The choice between the HumaCLIA 150 and iSYS should be based on the specific priorities and requirements of your laboratory. Considerations include testing volume, reagent and sample capacity, STAT sample handling, assay time, and cuvette management. By evaluating these factors, laboratories can make a well-informed decision that aligns with their operational needs and testing demands.


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