DiaSorin LIAISON XL or HumaCLIA 150: Which Immunoassay Analyzer To Choose?

Chemiluminescence immunoassay (CLIA) analyzers such as the HumaCLIA 150 and LIAISON XL offer advanced features and capabilities to meet the diverse needs of today's diagnostic laboratories. Understanding the specific benefits of each model can help you select the optimal instrument for your laboratory's needs.

*All information is correct as of March 2024

Selecting the right immunoassay analyzer can significantly enhance laboratory efficiency and accuracy. This comparison between the HUMAN HumaCLIA 150 and DiaSorin LIAISON XL highlights their key features to help you decide which one best meets your laboratory needs.

Type of Instrument

The type of instrument determines the space requirements and suitability for different laboratory setups. Both the HumaCLIA 150 and the LIAISON XL are benchtop analyzers designed for continuous access operation, allowing for uninterrupted addition of samples, reagents, and consumables to enhance workflow efficiency.

HumaCLIA 150: Ideal for laboratories with limited space needing high-performance analyzers.

LIAISON XL: Suitable for small to medium-sized laboratories requiring a versatile and compact analyzer.

Mode

The operational mode affects how samples and reagents are processed during the testing workflow. Both analyzers operate in continuous access mode, which provides consistent processing capability and accommodates varying sample volumes seamlessly.

HumaCLIA 150: Allows for uninterrupted sample and reagent addition, enhancing workflow efficiency.

LIAISON XL: Provides consistent processing capability, accommodating varying sample volumes seamlessly.

Detection Based On

The detection method is critical for sensitivity and specificity, impacting the accuracy of test results.

HumaCLIA 150: Utilizes Acridinium Ester (AE) for detection, a chemiluminescent substrate known for its high sensitivity and specificity.

LIAISON XL: Uses Acridinium ester-based immunoassay (ABEI), which is highly effective for a wide range of assays, providing robust performance and reliability.

Throughput (up to)

Throughput capacity is essential for laboratories that handle high sample volumes, as it determines how many tests can be processed within a given timeframe.

HumaCLIA 150: Offers a maximum throughput of 150 tests per hour, making it suitable for high-volume testing environments.

LIAISON XL: Provides a higher throughput of 180 tests per hour, ideal for laboratories with very high sample volumes.

Assay Time

Assay time affects the speed at which individual tests are completed, influencing overall laboratory throughput and efficiency.

HumaCLIA 150: Has an approximate assay time of 30 minutes, providing a balance between rapid processing and detailed analysis.

LIAISON XL: Offers a shorter assay time of approximately 17 minutes, making it suitable for laboratories needing rapid turnaround times.

Reagent Positions

The availability of reagent positions plays a critical role in supporting laboratories performing a wide range of tests. An increased number of reagent positions allows for greater testing flexibility and reduces the need for frequent reagent changes.

HumaCLIA 150: Equipped with 20 refrigerated reagent positions, providing versatility in conducting a diverse range of tests and minimizing the need for frequent reagent changes.

LIAISON XL: Features 15 refrigerated reagent positions, offering sufficient capacity for a variety of assays and efficient reagent management.

Sample Positions

Adequate sample positions are crucial for managing sample volumes effectively, preventing backlogs, and maintaining smooth laboratory operations.

HumaCLIA 150: Provides 50 sample positions, catering to higher sample volumes and including provisions for urgent STAT samples.

LIAISON XL: Offers 144 sample positions, effectively managing larger sample volumes and ensuring operational efficiency.

STAT Positions (Emergency Samples)

Handling STAT (emergency) samples efficiently is vital for clinical laboratories, ensuring priority processing without disrupting routine workflows.

HumaCLIA 150: Integrates STAT sample handling within its 50 sample positions, allowing for seamless inclusion of urgent tests in the workflow.

LIAISON XL: Includes dedicated STAT sample handling capabilities, ensuring that emergency samples are processed promptly, which is crucial for urgent diagnostic needs.

Reaction Cuvettes Onboard Capacity

The onboard capacity of reaction cuvettes affects how long the analyzer can operate without needing cuvette replacement, impacting efficiency and workflow continuity.

HumaCLIA 150: Boasts a substantial onboard capacity of 1000 reaction cuvettes, supporting extended continuous operation and reducing the frequency of interruptions for cuvette replacement.

LIAISON XL: Features an onboard capacity of 720 cuvettes, which provides ample capacity for continuous operations but may require more frequent replacements compared to the HumaCLIA 150.

Cuvette Format

The format of cuvettes can influence the ease of use, operational efficiency, and cost-effectiveness of the analyzer.

HumaCLIA 150: Uses single cuvettes in bulk format, advantageous for high-volume testing environments due to easier handling and lower costs.

LIAISON XL: Uses 6-cuvette-strips, which can provide flexible handling but may involve different cost and management considerations.

Conclusion

The choice between the HumaCLIA 150 and LIAISON XL should be based on the specific priorities and requirements of your laboratory. Considerations include testing volume, reagent and sample capacity, STAT sample handling, assay time, and cuvette management. By evaluating these factors, laboratories can make a well-informed decision that aligns with their operational needs and testing demands.

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