Biosystems A25 or HumaStar 300SR - which clinical chemistry system to choose?

The choice between the HumaStar 300SR and Biosystems A25 clinical chemistry analyzers depends on many factors and the specific needs of your laboratory. To determine which choice is more appropriate for your situation, it is important to consider the following critical aspects:

Company HUMAN Biosystems
Model HumaStar 300SR A25
Throughput max. tests/h 300 240
Reagent positions 40 30
Reagent cooling 13°C below RT Yes
Sample positions 60 72 (3x24)
Sample barcode reader Internal No
Cuvettes 80 re-usable Bionex 120 disposable
Water consumption (l/h) < 3 < 0.5

*All information is correct as of December 2023


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The efficiency of clinical chemistry analyzers is paramount for laboratories that handle varying sample volumes. Choosing a high-throughput analyzer is essential in high-volume testing environments to ensure that the laboratory's testing needs are met without bottlenecks or underutilization. Matching the throughput capacity to the specific needs of the laboratory is critical for optimal performance.

  • HumaStar 300SR: Demonstrating a robust maximum throughput of 300 tests per hour, the HumaStar 300SR excels in high-volume testing environments.
  • Biosystems A25: Offers a slightly lower maximum throughput of 240 tests per hour, suitable for laboratories with moderate sample volumes.

Reagent Positions

The availability of reagent positions plays a critical role in supporting laboratories performing a wide range of tests. A greater number of positions not only allows for greater test flexibility, but also reduces the need for frequent reagent changes. This feature is particularly important for laboratories seeking efficiency and versatility in their testing processes.

  • HumaStar 300SR: With 40 reagent positions, the HumaStar 300SR provides versatility in conducting a diverse range of tests, minimizing the need for frequent reagent changes.
  • Biosystems A25: Equipped with 30 reagent positions, providing a sufficient range of options for various tests.

Reagent cooling

Reagent stability is fundamental to the accuracy of clinical tests. The use of reagent cooling mechanisms is essential, especially for tests that are sensitive to temperature fluctuations. Maintaining reagents within specific temperature ranges ensures their integrity, contributing to accurate and reliable test results.

  • HumaStar 300SR: Ensures stable reagent temperatures at 13°C below room temperature, providing an optimal environment for preserving reagent integrity.
  • Biosystems A25: Incorporates reagent cooling, contributing to stable reagent conditions for accurate and reliable test results.

Sample Positions

Strategic sample positioning is essential for laboratories managing fluctuating sample volumes. Ensuring an adequate number of specimen locations is essential to efficiently process all patient specimens, mitigate the risk of specimen backlogs, and maintain operational fluidity.

  • HumaStar 300SR: Boasting a sample capacity of 60 positions, the HumaStar 300SR is suitable for laboratories managing higher sample volumes.
  • Biosystems A25: Provides an impressive 72 sample positions (3x24), accommodating a substantial number of samples in a single run.

Sample Barcode Reader

The integrity of the testing process is enhanced by the integration of specimen bar code readers. These readers reduce the risk of sample mix-ups and ensure that results are accurately linked to the appropriate patients. This feature is especially critical for clinical laboratories with high sample throughput, increasing overall testing accuracy and reliability.

  • HumaStar 300SR: Equipped with an internal sample barcode reader, enhancing the accuracy of sample identification.
  • Biosystems A25: Does not feature a sample barcode reader.


The type and capacity of cuvettes used in clinical chemistry analyzers have a significant impact on consumables costs, the number of tests performed before cuvette replacement, and the overall environmental footprint. A nuanced understanding of cuvette configuration is critical to making informed decisions that balance cost effectiveness and operational efficiency.

  • HumaStar 300SR: Utilizes 80 re-usable Bionex cuvettes, contributing to a larger cuvette capacity and cost-effective operational practices.
  • Biosystems A25: Uses 120 disposable cuvettes, offering a different cuvette type that may impact consumable costs.

Water Consumption

Monitoring water consumption is emerging as a key aspect of responsible laboratory management. Controlling operating costs and minimizing environmental impact are achieved through strategies that reduce water consumption. Implementing measures to reduce water consumption not only results in cost savings, but also aligns with the laboratory's sustainability efforts and contributes to a more environmentally conscious operation.

  • HumaStar 300SR: Boasts a lower water consumption rate of less than 3 liters per hour, contributing to cost efficiency and environmental sustainability.
  • Biosystems A25: Demonstrates an extremely low water consumption rate of less than 0.5 liters per hour, enhancing operational cost efficiency.


  • HumaStar 300SR: Recognized for its high sample capacity, cost-effective use of re-usable Bionex cuvettes, and environmental sustainability focus.

  • Biosystems A25: Offers an extensive sample position capacity, reagent cooling, and an extremely low water consumption rate, catering to laboratories with specific operational needs.

    In conclusion, the choice between the HumaStar 300SR and Biosystems A25 should be based on the specific priorities and requirements of your laboratory. Considerations include testing volume, the range of tests needed, water consumption, the importance of a sample barcode reader, and cuvette preferences in your testing processes. The additional information provides insights into the specific strengths of each analyzer, facilitating a well-informed decision based on your laboratory's unique needs.