Products
Rheumatism
Connective Tissue Diseases & Rheumatoid Arthritis – The Staged Multimarker Concept
Pain in joints and muscles, stiff knees, back pain, swollen and red joints comprise the typical symptoms associated with the generic term "rheumatism". A
total of about 450 different diseases are grouped together under this term.
Their commonality is pain. In Germany about 20 million people suffer from the
various forms of this disease.
Rheumatic diseases can affect joints and/or the connective tissue.
Because of the incredible diversity of rheumatic diseases these are divided into two major groups:
- Connective tissue diseases
- Rheuma / rheumatism
The classification presented here is only one possible structuring, but is
widespread. However, the nomenclature and classification of rheumatic diseases
are not uniformly regulated.
Connective Tissue Diseases
Connective Tissue Diseases are a group of rare autoimmune diseases in which the
immune system recognizes parts of the body's connective tissue (collagen) as
foreign, and initializes antibody production against them. Since the connective
tissue is of mayor importance in many different organs,collagenosis often occurs
in many organs at once, such as the skin, mucous membranes, lungs, heart or blood vessels - all of which are attacked simultaneously.
The disease course is usually chronic and can affect all physiological aspects of the afflicted patients. Women are diagnosed much more frequently
than men, and the disease usually occurs in middle age.
Rheumatoid Arthritis – The Staged Multimarker Concept
An early diagnosis of rheumatoid arthritis (RA) can prevent the loss of mobility and
the destruction of the joints. The usual serodiagnosis of RA (rheumatoid factor
and CRP) alone is not sufficient, however, since rheumatoid factors are unspecific (and may also be evidence of other autoimmune disorders and infections). On the other hand, antibodies against cyclic citrullinated peptide (CCP) are almost exclusively
present in patients with rheumatoid arthritis (specificity up to 98%). Up to
30% of early RA patients are RF and / or CCP seronegative.
Here the
detection of anti-RA33 antibodies allows the diagnosis of these patients and may permit a mild disease course with less damage to joints.
Regardless of
anti-CCP and RF, anti-RA33 antibodies are present in the early phase of RA and can be recognized years before the clinical onset of the disease. A
combined diagnosis with three serological markers offers optimal diagnostic
sensitivity.
For more information, please select from the following list:
Connective Tissue Diseases
IMTEC-ANA Screen
ELISA for the Quantitative Determination of Antinuclear Antibodies (Ig(GAM)) | 96 Tests
ITC60001
IMTEC-ANA Screen (cut-off)
ELISA for the Determination of Antinuclear Antibodies (IgG) | 96 Tests
ITC70001
IMTEC-ENA Screen
ELISA for the Quantitative Determination of Extractable Antinuclear Antibodies (IgG) | 96 Tests
ITC60005
IMTEC-ENA Screen (cut-off)
ELISA for the Detection of Anti-ENA-Antibodies (IgG) | 96 Tests
ITC70005
IMTEC-ANA/ENA Combi Screen (cut-off)
ELISA for the Detection of ANA and Anti-ENA-Antibodies (Ig(GAM)) | 96 Tests
ITC70000
IMTEC-ENA Profile
ELISA for the Detection of Anti-ENA Antibodies (IgG) | 96 Tests
ITC60033
IMTEC-dsDNA-Antibodies
ELISA for the Quantitative Determination of Anti-dsDNA Antibodies (IgG) | 96 Tests
ITC59001
IMTEC-Anti-C1q-Antibodies
ELISA for the Quantitative Determination of Anti-C1q Antibodies (IgG) | 96 Tests
ITC59033
IMTEC-ssDNA-Antibodies
ELISA for the Quantitative Determination of Anti-ssDNA Antibodies (IgG) | 96Tests
ITC59005
IMTEC-Nucleosome-Antibodies
ELISA for the Quantitative Determination of Anti-Nukleosom Antibodies (IgG) | 96 Tests
ITC59002
IMTEC-SS-A/Ro-Antibodies (cut-off)
ELISA for the Detection of Anti-SS-A/Ro Antibodies (IgG) | 96 Tests
ITC70026
IMTEC-SS-B/La-Antibodies (cut-off)
ELISA for the Detection of Anti-SS-B/La Antibodies (IgG) | 96 Tests
ITC70024
IMTEC-SmD1-Antibodies
ELISA for the Quantitative Determination of Anti-SmD1 Antibodies (IgG) | 96 Tests
ITC60029
IMTEC-SmD1 Antibodies (cut-off)
ELISA for the Detection of Anti-SmD1 Antibodies (IgG) | 96 Tests
ITC70029
IMTEC-U1-SnRNP Antibodies (cut-off)
ELISA for the Detection of Anti-U1-SnRNP Antibodies (IgG) | 96 Tests
ITC70022
IMTEC-Histone-Antibodies
ELISA for the Quantitative Determination of Anti-Histon Antibodies (IgG) | 96 Tests
ITC60031
IMTEC-Histone-Antibodies (cut-off)
ELISA for the Detection of Anti-Histon Antibodies (IgG) | 96 Tests
ITC70031
IMTEC-Scl70-Antibodies (cut-off)
ELISA for the Detection of Anti-Scl 70 Antibodies (IgG) | 96 Tests
ITC70028
IMTEC-Jo1-Antibodies (cut-off)
ELISA for the Detection of Anti-Jo1 Antibodies (IgG) | 96 Tests
ITC70025
IMTEC-PM-Scl-Antibodies (cut-off)
ELISA for the Detection of Anti-PM-Scl Antibodies (IgG) | 96 Tests
ITC70035
IMTEC-ANA-LIA-Maxx
Line Immuno Assay for simultanous Detection of 17 Antinuclear Antibodies (IgG) | 24 Tests
ITC92005
IMTEC-ANA-LIA
Line Immuno Assay for simultanous Detection of 11 Antinuclear Antibodies (IgG) | 24 Tests
ITC92000
IMTEC-Myositis-LIA
Line Immuno Assay for simultanous Detection of Jo1, Mi2, PM-Scl, U1-snRNP, Ku (IgG) | 24 Tests
ITC60200
Rheumatoid Arthritis – The Staged Multimarker Concept
IMTEC-RF Screen
ELISA for the Quantitative Determination of Rheumatoid Factors (Ig(GAM)) | 96 Tests
ITC60000
IMTEC-RF IgM
ELISA for the Quantitative Determination of Rheumatoid Factors (IgM) | 96 Tests
ITC60003
IMTEC-RF IgG
ELISA for the Quantitative Determination of Rheumatoid Factors (IgG) | 96 Tests
ITC60007
IMTEC-RF IgA
ELISA for the Quantitative Determination of Rheumatoid Factors (IgA) | 96 Tests
ITC60010
IMTEC-CCP-Antibodies
ELISA for the Quantitative Determination of Antibodies against Cyclic Citrullinated Peptide (IgG) | 96 Tests
ITC60021
IMTEC-RA33-Antibodies
ELISA for the Quantitative Determination of Anti-RA33-Antibodies (IgG) | 96 Tests
ITC60015
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